Risk Profiles in Individual Software Development and Packaged Software Implementation Projects: A Delphi Study at a German-Based Financial Services Company

The aim of this paper is to compare risk profiles of individual software development (ISD) and packaged software implementation (PSI) projects. While researchers have investigated risks in either PSI projects or ISD projects, an integrated perspective on how the risk profiles of these two types of information system (IS) projects differ is missing. To explore these differences, this work conducted a Delphi study at a German-based financial services company. The results suggest that: First, ISD projects seem to be more heterogeneous and face a larger variety of risks than the more straightforward PSI projects. Second, ISD projects seem to be particularly prone to risks related to sponsorship, requirements, and project organization. Third, PSI projects tend to be predominantly subject to risks related to technology, project planning, and project completion. Finally, in contrast to available lists of risks in IS projects and irrespective of the project type, the paper found a surprisingly high prominence of technology and testing-related risks

Reproductive non-seasonality in rhinoceroses: A review of the in-situ literature and birth records of ex-situ institutions

Mammals whose breeding activity is triggered by seasonal photoperiodic cues typically maintain seasonal reproduction in zoos, with births accumulating to various degrees in spring. For zoo-kept rhinoceroses, accumulation of births in autumn has been suggested, which would make this group unusual. We compare birthing (and hence conception) patterns of free-ranging rhinoceros populations from the scientific literature with those of the global zoo populations based on birth data available from Species360, to facilitate deductions on the cues that trigger rhinoceros reproduction. The patterns do not indicate a photoperiodic element in rhinoceros reproduction but suggest suppression of conception in free-ranging populations at times of resource scarcity. This is not evident in zoos. However, a slight accumulation of autumn births, due to a slight reduction in births in spring, is visible in the zoo populations. Given rhinoceros gestation periods, this is linked to reduced conceptions in November–December. The most parsimonious interpretation is management-related, as has been suggested (Roth 2006, Int. Zoo Yb. 40(1): 130–143): not all facilities are prepared to allow mating at times when outdoor husbandry is reduced due to weather restrictions. Given the long interbirth intervals of rhinoceroses, missed conception opportunities of 1–2 months are unlikely to affect population demographics. Nevertheless, detailed recording of approaches to facilitate mating during winter months by those zoos that achieve this may increase the general skill of rhinoceros management

Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies

The stromal vascular fraction (SVF) of adipose tissue contains an abundant population of multipotent adipose-tissue-derived stem cells (ASCs) that possess the capacity to differentiate into cells of the mesodermal lineage in vitro. For cell-based therapies, an advantageous approach would be to harvest these SVF cells and give them back to the patient within a single surgical procedure, thereby avoiding lengthy and costly in vitro culturing steps. However, this requires SVF-isolates to contain sufficient ASCs capable of differentiating into the desired cell lineage. We have investigated whether the yield and function of ASCs are affected by the anatomical sites most frequently used for harvesting adipose tissue: the abdomen and hip/thigh region. The frequency of ASCs in the SVF of adipose tissue from the abdomen and hip/thigh region was determined in limiting dilution and colony-forming unit (CFU) assays. The capacity of these ASCs to differentiate into the chondrogenic and osteogenic pathways was investigated by quantitative real-time polymerase chain reaction and (immuno)histochemistry. A significant difference (P = 0.0009) was seen in ASC frequency but not in the absolute number of nucleated cells between adipose tissue harvested from the abdomen (5.1 ± 1.1%, mean ± SEM) and hip/thigh region (1.2 ± 0.7%). However, within the CFUs derived from both tissues, the frequency of CFUs having osteogenic differentiation potential was the same. When cultured, homogeneous cell populations were obtained with similar growth kinetics and phenotype. No differences were detected in differentiation capacity between ASCs from both tissue-harvesting sites. We conclude that the yield of ASCs, but not the total amount of nucleated cells per volume or the ASC proliferation and differentiation capacities, are dependent on the tissue-harvesting site. The abdomen seems to be preferable to the hip/thigh region for harvesting adipose tissue, in particular when considering SVF cells for stem-cell-based therapies in one-step surgical procedures for skeletal tissue engineering

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

Predicting the clinical outcome of cancer patients based on the expression of marker genes in their tumors has received increasing interest in the past decade. Accurate predictors of outcome and response to therapy could be used to personalize and thereby improve therapy. However, state of the art methods used so far often found marker genes with limited prediction accuracy, limited reproducibility, and unclear biological relevance. To address this problem, we developed a novel computational approach to identify genes prognostic for outcome that couples gene expression measurements from primary tumor samples with a network of known relationships between the genes. Our approach ranks genes according to their prognostic relevance using both expression and network information in a manner similar to Google's PageRank. We applied this method to gene expression profiles which we obtained from 30 patients with pancreatic cancer, and identified seven candidate marker genes prognostic for outcome. Compared to genes found with state of the art methods, such as Pearson correlation of gene expression with survival time, we improve the prediction accuracy by up to 7%. Accuracies were assessed using support vector machine classifiers and Monte Carlo cross-validation. We then validated the prognostic value of our seven candidate markers using immunohistochemistry on an independent set of 412 pancreatic cancer samples. Notably, signatures derived from our candidate markers were independently predictive of outcome and superior to established clinical prognostic factors such as grade, tumor size, and nodal status. As the amount of genomic data of individual tumors grows rapidly, our algorithm meets the need for powerful computational approaches that are key to exploit these data for personalized cancer therapies in clinical practice

Comparing risks in individual software development and standard software implementation projects: A delphi study

This paper aims at exploring differences in risk profiles across various types of IS projects. IS project managers face a variety of risks. Before taking appropriate countermeasures, the first step in successfully managing risks is to identify and prioritize them. While many researchers have investigated risks in IS projects in general, few take into account the specific nature of different types of IS projects. However, discrepancies in extant risk rankings suggest that a project\u27s risk profile changes depending on which type of project is being investigated. In order to explore these differences across IS project types we conducted a Delphi study at a German-based financial services company in order to identify and compare the risk profiles of individual software development and standard software implementation projects. Our results comprise (a) a list of 100 distinct IS project risks, which not only includes new risks but also emphasizes the importance of technical risks, and (b) ranked risk profiles for different types of IS projects. The heterogeneity of the risk profiles suggests that while there are indeed project-generic risks which are likely to occur across different types of IS projects, project-type-specific risks do considerably influence a project\u27s risk profile

The Hidden Benefits of Limited Communication and Slow Sensing in Collective Monitoring of Dynamic Environments

Most of our experiences, as well as our intuition, are usually built on a linear understanding of systems and processes. Complex systems in general, and more specifically swarm robotics in this context, leverage non-linear effects to self-organize and to ensure that ‘more is different’. In previous work, the non-linear and therefore counter-intuitive effect of ‘less is more’ was shown for a site-selection swarm scenario. Although it seems intuitive that being able to communicate over longer distances should be beneficial, swarms were found to sometimes profit from communication limitations. Here, we build on this work and show the same effect for the collective perception scenario in a dynamic environment. We also find an additional effect that we call ‘slower is faster’: in certain situations, swarms benefit from sampling their environment less frequently. Our findings are supported by an intensive empirical approach and a mean-field model. All our experimental work is based on simulations using the ARGoS simulator extended with a simulator of the smart environment for the Kilobot robot called Kilogrid.info:eu-repo/semantics/publishedANTS (Conference :Swarm intelligence) & Dorigo M. (2022). Swarm intelligence :13th international conference ants 2022 málaga spain november 2-4 2022 proceedings. Springer. https://doi.org/10.1007/978-3-031-20176-

The paradox of organizational compensation practices: Why does HRM act as-if labor income inequality does not exist?

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Moving Beyond the Link Between HRM and Economic Performance: A Study on the Individual Reactions of HR Managers and Professionals to Sustainable HRM.

This study contributes to the growing literature on the intersection between human resource management and corporate sustainability (CS) and, in particular, on sustainable human resource management (interpreted here as HRM practices informed by the CS principles, thus aiming at economic, social, environmental and human sustainability simultaneously). In particular, this paper claims that the members of the HR professional community can increase their job satisfaction and decrease their intention to leave by implementing sustainable HRM. In addition, we test for the mediating role played by the meaning that HR professionals and managers attach to HR work. Indeed, when HR professionals and managers are involved in sustainable HRM perceive their job to become more meaningful as it has a broader scope which goes beyond the solely focus on economic performance, and that leads then to higher job satisfaction and lower turnover intention. The study, which is based on 176 questionnaires collected through a cross-country survey, has been developed in partnership between the authors and a leading European association of HR managers and professionals. Our findings, which in general extend the knowledge on the employees’ perception of CS—employee attitudes relationships, represent a data-driven argument for a more active role of HRM in developing Sustainable HRM